These are the calibration settings that we used for our review of the Vizio E Series 2017. These settings will work well for everything even gaming, with a few modifications listed below.
Start by choosing the 'Calibrated dark' picture mode, as this is the mode which allows the most flexibility over picture settings. For our calibration process, we set the 'Backlight' to 35 to reach our goal luminance of 100 cd/m². If you are in a bright room, or find our settings too dark, increase 'Backlight' as much as you want and it won't change the colors. We left the 'Brightness to 50, 'Contrast' to 50 and 'Color' to 50, their default values. We did not need to change these values to reach our calibration goal.
We also left 'Tint' untouched a 0, its default value. We selected the 'Normal' 'Color Temperature' since it gave us the closest result toward our calibration goal, but if you find the color to warm you can change it for a cooler color temperature. We left 'Black Detail' off, since it added some image processing and we aim to be as true as possible to the original content. For the calibration, we also left 'Active LED Zones' off. The size of the dimming zones are so big and do not work well enough that we felt it was better to leave them off. We also left 'Clear Action' off, but this could be turned on to clear motion, especially when watching fast space action content. For more information about the 'Clear Action' option, you can read this section of the review.
We left the 'Reduce Block Noise' off for our calibration, but if you see too many artifacts or too much noise when watching low-quality content, enable the noise reduction features. Keep in mind that these soften the picture, so don't turn them on for high-quality content. We set the gamma to 2.2 since it is closest to our calibration goal. We also set the 'Film Mode' and 'Color Space' to 'Auto' since when set to 'Auto', the TV will select the best setting based on the content playing.
On the Vizio E Series 2017, the most important setting to turn on is the 'Game Low Latency' option. The picture mode you are in does not really change anything to the input lag, so you can be in 'Calibrated dark' and just turn on 'Game Low Latency' and you should have the best input lag available. All HDMI port have the same input lag.
HDR can only be played via a device (Blu-rays players or video game console) connected via the HDMI port 1 and with 'HDMI Color Subsampling' turned on for this port. To access this option, you need to go in the 'Inputs' settings via the main 'Display Settings'.
The following are the results of the white balance and colorspace calibration on our unit. They are provided for reference, and should not be copied as the calibration values vary per individual unit even for the same model and same size as the TV we reviewed due to manufacturing tolerances. If you want to try them you will need to enter all values shown, as all of them are active at the same time. If you end up with worse picture quality, simply reset them to the default values.