If long workdays or marathon gaming sessions see you spending a lot of time glued to your computer, conventional mouse designs may not meet your comfort or health needs. Thankfully, ergonomic mouse designs with sculpted shapes, thumb rests, and even vertical orientations are becoming increasingly common. These features contribute to a more comfortable and less fatiguing experience. To help you find the right ergonomic design for your needs, we've curated a selection of the top ergonomic mice, focusing on ergonomic compatibility, button placement, and comfort.