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The Best Ergonomic Mouse - Spring 2022 Mice Reviews

Best Ergonomic Mouse

As many of us are spending longer times with our computers, you may find the straight, ambidextrous designs of most mice uncomfortable at the end of long workdays or gaming sessions. Thankfully, there are an increasing number of mouse designs with sculpted shapes, thumb rests, and other ergonomic elements. These elements can help contribute to a more comfortable user experience. The following mice are a selection of the best of these designs focusing on ergonomic compatibility, button reachability, and user comfort.

We've tested over 250 mice, and below are our top picks for the best ergonomic options. For other recommendations, be sure to check out our picks for the best wireless mice, the best mice, and the best wired mice.

  1. Best Ergonomic Mouse For Office Use: Logitech MX Master 3

    The best ergonomic mouse for office use that we've tested is the Logitech MX Master 3. Its body is made of solid plastic with a soft-touch texture, and it feels incredibly well-built overall. It has an ergonomic, right-handed shape that feels remarkably comfortable. However, It's on the larger side and is best suited for medium-sized or larger hands using a palm or claw grip.

    You can press its large thumb rest section to enable gesture controls, and its primary scroll wheel unlocks automatically for faster free-scrolling whenever you're scrolling quickly through a long document. There's also a second, side-mounted scroll wheel within reach of your thumb that you can use to navigate documents horizontally, which is helpful if you deal with long tables or spreadsheets. This mouse connects wirelessly via Bluetooth or its proprietary receiver and can pair with up to three devices simultaneously.

    Unfortunately, it's expensive, and due to its size, it isn't suitable for small hands, regardless of grip type. It's also bulky and unlikely to fit in most laptop bags, and it lacks a built-in storage compartment for its wireless USB receiver, making it less than ideal for travel. There's also no onboard memory, so you'll need to install the software if you want to use your custom settings on a different computer. That said, this is an outstanding and luxurious workhorse option packed with helpful features for productivity.

    See our review

  2. Cheaper Alternative: Logitech MX Master 2S

    If you're interested in the feature set and comfort of the Logitech MX Master 3 but are looking for a more affordable option, you'll want to consider the previous generation Logitech MX Master 2S. It's not quite as well laid-out as the MX Master 3, with a slightly more difficult-to-reach side scroll wheel and side buttons, but it's typically on sale for much cheaper, and its feet glide more smoothly on mousepads and directly on desks. It feels just as comfortable and well-built and has the same right-slanted shape made with tough and premium-feeling plastic. Unfortunately, it isn't suitable for small hands. Also, its charging cable has an older micro-USB connector which doesn't charge quite as quickly as the newer USB-C cable on the MX Master 3.

    If you want a more recent ergonomic office mouse with more convenient button placements, go with the MX Master 3. However, if you want a very similar and much more affordable option with better mouse feet, get the MX Master 2S.

    See our review

  3. Best Vertical Mouse: Logitech MX Vertical

    If you're looking for a mouse with a vertical design, we recommend the Logitech MX Vertical. The design is intended to reduce wrist strain by allowing you to rest your hand and wrist on your desk, avoiding pronation that can compress nerves in your forearm and wrist. Due to its size and style, it's best suited for a claw or palm grip.

    It feels very well-built and has a textured surface that provides additional grip. It connects wirelessly via Bluetooth or its USB receiver, or you can use it while it charges with its charging cable. You can also wirelessly pair it with up to three devices. The Logitech Options software is compatible with both Windows and macOS, and you can use it to create custom profiles and assign button configurations for specific programs.

    Unfortunately, it's bulky, so it isn't a good option if you're looking for a more portable mouse. The scroll wheel doesn't unlock for free scrolling, which can make scrolling through long documents more tedious. Also, the vertical design differs quite a bit from more traditional mice shapes, so it may take you some time to get used to it. With that said, it's a great choice if you're looking for a mouse with a vertical orientation to keep pressure off your forearm and wrist.

    See our review

  4. Best Budget Vertical Mouse: Anker Wireless Vertical Mouse

    While the Logitech MX Vertical is a great choice, it's also expensive. For a more affordable option, the Anker Wireless Vertical Mouse is a great bet. It has a fairly slim and comfortable right-slanted shape and feels quite sturdy and well-built, especially given its price point. There are two side buttons on the left and a pair of left- and right-click buttons on the right side, along with a conventional scroll wheel.

    It connects wirelessly with its USB receiver and uses a pair of AAA batteries for power. However, there's also a variant with a rechargeable battery if you'd prefer. There's also a storage compartment for the USB receiver when it's not in use, which is helpful to ensure you don't lose your receiver if you plan on using it on the go, away from your home setup.

    Unfortunately, it doesn't support Bluetooth, and the scroll wheel lacks both L/R tilt buttons and a free-scrolling mode, which are more common features on more premium-priced productivity options. Also, it lacks customization software, so you can't remap keys or adjust sensor settings. Despite these shortcomings, this is a great entry-level vertical mouse typically available for around half the price of more premium options like the Logitech MX Vertical.

    See our review

  5. Best Ergonomic Gaming Mouse: Razer Basilisk V3

    The best ergonomic gaming mouse we've tested is the Razer Basilisk V3. It has a right-handed shape with a thumb rest that provides more support than some other mice with more straightforward, streamlined shapes. While many gaming mice only have two side buttons on the left, the Basilisk V3 has a third button that's designated as a sniper button. By default, this sniper button lowers your CPI setting while you hold it so you can line up more precise shots, then let the button go and resume your normal CPI setting.

    Using the customization software, you can reprogram this sniper button, along with all the rest of the buttons. The software also allows you to precisely adjust the set CPI in increments of 50 within a very wide range, adjust sensor settings, and customize the RGB lighting. Performance-wise, It has exceptionally low click latency and a very low minimum lift-off distance. Also, the scroll wheel has L/R tilt inputs and a free-scrolling mode that you can toggle to enable automatically when you scroll to a certain speed.

    Unfortunately, this mouse is heavy and bulky. You may have difficulty reaching the sniper button with a claw or fingertip grip if you have small hands. It's also wired-only, but its cable is quite flexible and doesn't cause drag on desks or mousepads. Altogether, this mouse is a versatile option if you're looking to add extra comfort and customizability to your gaming sessions.

    See our review

  6. Best Ultra-Light Ergonomic Mouse For Gaming: Cooler Master MM720

    The best ultra-lightweight ergonomic gaming mouse we've tested is the Cooler Master MM720. It has an unconventional right-handed shape with a ring finger rest for additional support. Its honeycomb body makes it exceptionally light, and its high-quality feet and cable provide a smooth gliding experience on mousepads or desks with little drag.

    It feels incredibly responsive to use thanks to its outstanding click latency, and its low lift-off distance means you can easily lift and reposition the mouse without the sensor picking up any unintended cursor movements. You can reprogram all of the buttons, customize your sensor settings, and save profiles to the mouse's onboard memory using the companion software. The companion software also allows you to customize the RGB to best suit your aesthetic.

    Unfortunately, it doesn't feel as solidly built as some other honeycomb options, so there's a bit of flex in its body when pressed. Also, its sensor tends to undershoot the set CPI considerably during quick mouse movements. With that said, it's a great choice if you're looking for a comfortable ultra-light gaming mouse.

    See our review

  7. Best Budget Ergonomic Mouse: Logitech M720 Triathlon

    In the budget category, the best wireless ergonomic mouse we've tested is the Logitech M720 Triathlon. It has a comfortable right-handed shape with a humped back and a thumb rest on the left side. It's well-suited for every hand size using a fingertip grip.

    It has great office-oriented features like a hidden button on the thumb rest that enables custom gesture commands and a button below the scroll wheel that unlocks a free-scrolling mode that makes navigating long documents much quicker. It connects wirelessly via Bluetooth or with its USB receiver, and there's also a storage compartment for the receiver inside the mouse, so it doesn't get lost when it's not in use. Also, the Logitech Options companion software is compatible with Windows and macOS and allows you to reprogram buttons and customize sensor settings.

    Unfortunately, its high back makes this mouse fairly bulky, so it may not fit easily into most laptop cases. Its shape also isn't ideal if you have larger hands and typically use a claw or palm grip. With that said, it's an excellent and comfortable choice with a surprising feature set if you're looking for a wireless office mouse on a budget.

    See our review

  8. Best Ergonomic Trackball Mouse: Logitech MX ERGO

    If you're looking for a trackball mouse, look no further than the Logitech MX ERGO. It features a right-handed slanted design with a trackball on the left side under your thumb to move the cursor. It's a stationary mouse, so its design reduces wrist strain during those long workdays since you don't need to use wrist or arm movements to control it.

    It feels very well-built and solid, and there's also a pinky rest, so none of your fingers should hang awkwardly off the edge of the mouse. It connects wirelessly using its USB receiver or via Bluetooth, and it uses a rechargeable battery for power. Unlike other trackball mice that use a ring around the trackball for scrolling, this mouse has a more typical-looking scroll wheel with L/R tilts for easy horizontal navigation through spreadsheets or video timelines. You can also reprogram all of its buttons to best suit your workflow.

    Unfortunately, its scroll wheel doesn't unlock for free scrolling, which might be annoying if you spend a lot of time navigating long documents. It also has a low, fixed polling rate, so it's not very versatile and isn't suitable for gaming use. With that said, it's a good choice if you're looking for a trackball mouse with a comfortable, ergonomic design.

    See our review

Notable Mentions

  • XTRFY M4 RGB: The XTRFY M4 RGB is an excellent ultra-light gaming mouse if you have larger hands and use a palm or claw grip, but its click latency and CPI range aren't as good as the Cooler Master MM720. See our review
  • GLORIOUS Model D: The Glorious Model D is an excellent alternative to the Cooler Master MM720 if you have larger hands, but it has higher click latency and a higher minimum lift-off distance. See our review
  • Mad Catz R.A.T. 8+: The Mad Catz R.A.T. 8+ is a decent wired gaming mouse with a modular design that allows for a lot of customization, but it doesn't perform as well as other gaming options. See our review
  • Razer Pro Click: The Razer Pro Click is an excellent alternative to the Logitech MX Master 3 if you have smaller hands, but you can't unlock its wheel for free scrolling, and it doesn't support gesture commands. See our review

Recent Updates

  1. Apr 22, 2022: We've transformed the 'Cheaper Alternative' category into a new 'Best Budget Vertical Mouse' category, keeping the Anker Wireless Vertical Mouse as our pick. We've also confirmed all other choices for relevance and continued availability, and we made minor adjustments to the text for clarity.

  2. Feb 22, 2022: Made several minor changes to the text for clarity and confirmed all recommendations remain the best choices currently available for their respective categories.

  3. Dec 24, 2021: Moved the Cooler Master MM720 to 'Best Ultra-Light Ergonomic Mouse For Gaming'. Replaced the Razer Basilisk V2 with the Razer Basilisk V3 as 'Best Ergonomic Mouse For Gaming' for consistency across articles. Added the Logitech MX ERGO as 'Best Ergonomic Trackball Mouse'.

  4. Nov 02, 2021: Verified picks for accuracy and availability; no changes to picks.

  5. Sep 03, 2021: Replaced the XTRFY M42 with the XTRFY M4 RGB in the Notable Mentions because the M4's right-handed shape is more ergonomic than the M42's ambidextrous shape. Added the Glorious Model D to Notable Mentions.

All Reviews

Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).

If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.