If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long work day. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for long term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design and have easy-to-reach buttons.
We've reviewed over 60 mice, and below are our top picks for the best ergonomic mouse. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best ergonomic mouse we've tested so far if you're looking for something to use at the office is the Logitech MX Master 3. This mouse has a very professional look with a right-slanted design, on top of having a large thumb rest for a very comfortable hand position. It's great for people that use a palm grip. This mouse can be used via Bluetooth and with its USB receiver, which makes it quite versatile.
While it doesn't perform as well as high-end gaming mice, it's mainly aiming at making your office workflow smoother. It has an unlockable mouse wheel for infinite scrolling through long documents and it even has a second side-scrolling wheel. The thumb rest also features a button that can be used to trigger gesture commands and you can set different profiles for different programs and apps you're using.
Unfortunately, it's quite heavy, so you'll need to find a sensitivity that won't require you to lift the mouse often, and its wide and large body won't be the best option if you have smaller hands. On the other hand, this professional mouse makes workflow more fluid and it's one of the better-built and more premium mice we've reviewed so far.
If you're shopping on a tight budget, take a look at the Logitech MX Master 2S. Its design and features are very similar to the Logitech MX Master 3, but it's slightly heavier and its side buttons are a bit harder to press due to their placement. There are five programmable buttons and it has a slightly higher polling rate, which makes mouse movements feel a bit smoother. You still get great customization options through its companion software as well as excellent compatibility with Windows and macOS, and it can be paired to three devices at the same time to make multitasking a breeze.
Overall, the MX Master 3 is slightly better if you can afford it, but the MX Master 2S can perform almost as well and is significantly cheaper.
The best vertical mouse that we've tested so far is the Logitech MX Vertical. Vertical mice aim to reduce the pronation of the forearm and put your arm in a more natural position. This should help people that feel a lot of tension in their wrist or forearm after a long work day. This mouse is from the professional MX lineup, just like the Logitech MX Master 3 and the Logitech MX Master 2. It's very well-built and its design is better suited for a palm grip.
Its overall wireless performance is good enough for the office, but won't be on-par with gaming mice, which is to be expected. You can use this mouse via Bluetooth, with its USB receiver, or even when charging with a cable, making it quite versatile. It's easy to use, although some people might require a bit of time to get used to its vertical design.
Additionally, this very large body won't be great for people with small hands as they might have trouble reaching the scroll wheel. Also, even if it's Bluetooth-enabled, bringing it around is a bit difficult, so it's best to stay at your work desk. On the upside, just like most Logitech mice, it's fully compatible and customizable on macOS and Windows.
The best ergonomic mouse for gaming that we've tested is the Corsair GLAIVE PRO. It's worth noting that most gaming mice aren't necessarily designed with pure ergonomics in mind, but the slanted design and swappable grip options make this the best option if you want something comfortable for long gaming sessions. While it isn't the best gaming mouse we've tested so far, this wired gaming mouse comes with three different side panels to help get you a comfortable fit: one with a thumb rest, and two with different grip patterns.
The sensor performance is excellent, and it has a wide adjustable CPI range that can be set by increments of 1, so you can fine-tune it to match your preferences. It has two additional side buttons, a CPI up and CPI down button on the top, and a scroll wheel click, all of which can be reprogrammed within Corsair's excellent iCUE software. The software is compatible with both Windows and macOS, which is fairly rare for a gaming mouse and allows you to customize every aspect of the mouse.
Unfortunately, like many wired gaming mice, the cable is rather stiff and maintains a lot of kinks from its packaging. On the upside, the mouse is suitable for a wide variety of hand sizes, and everyone should be able to easily reach every button with a claw grip, while only extra-large hands will likely have difficulties with palm grip. Overall, if you're looking for a gaming mouse for extended gaming sessions, the slanted design and swappable grip panels make this the most comfortable option.
The best ergonomic mouse in the budget category that we've tested to date is the Anker Wireless Vertical Mouse. This wireless mouse has a fairly standard vertical design and feels surprisingly well-made for its low price point. It's very comfortable to use and its vertical design puts your wrist in a more neutral position. It's designed to use with a palm grip, though its larger size means people with small hands may have difficulty reaching all the buttons comfortably.
While its click latency is quite high, this mouse isn't designed for gaming and it's unlikely that you'll notice any lag or delay in regular everyday use. Unfortunately, though its CPI is adjustable, even the lowest setting is high, which will result in cursor movement that may be too fast for most people, so you may need to change your cursor speed in your OS settings. Also, while the mouse has two buttons that are well-placed by your thumb, there's no companion software, so you can't reprogram them without using third-party software.
Overall, this is a fairly decent ergonomic mouse that looks and feels more premium than its low price point may suggest. While we don't do any testing on the long-term effects of vertical mice, they're advertised as being more natural and many people seem to find them more comfortable after using a computer all day at work. If you're curious about trying out a vertical mouse but don't want to spend a ton, this is a great choice.
05/04/2020: Minor text and structure changes; no change in recommendations.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our reviews of mice. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.