If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for the long-term effects of ergonomic mice, the following mice all have a somewhat slanted and comfortable design and have easy-to-reach buttons.
We've tested over 185 mice, and below are our top picks for the best mouse for ergonomics. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best ergonomic mouse for office use that we've tested is the Logitech MX Master 3. It's made of solid plastic and feels incredibly well-built, featuring an ergonomic, right-slanted design that feels remarkably comfortable. It's on the larger side and is best suited for medium-sized or larger hands using a palm or claw grip.
Its large thumb rest section can be pressed to enable gesture controls, while its vertical scroll wheel unlocks automatically for free scrolling whenever you're scrolling quickly. There's also a side scroll wheel above the two left side buttons. It connects wirelessly via Bluetooth or its proprietary receiver and can pair with up to three devices simultaneously. You can use the companion software to reprogram most of its buttons and set custom profiles with different settings for different programs.
Unfortunately, it's quite large and isn't suited for small hands, regardless of grip type. Due to its size, it might not fit into most laptop bags, and it also doesn't have built-in storage for its wireless receiver, which makes it less than ideal for travel. There's also no onboard memory, so you'll need to change the settings whenever you move to a different computer. All in all, this is an outstanding mouse that's packed with features for productivity, and it's among the best mice we've tested.
If you want to spend a bit less for an office mouse that's just as comfortable, consider the Logitech MX Master 2S. It's a bit worse for ergonomics than the Logitech MX Master 3, with a slightly more difficult-to-reach side scroll wheel, and side buttons, but it's cheaper and its slightly higher maximum polling rate should make cursor movements more fluid. Also, its feet glide more smoothly on mousepads and directly on desks. It's just as comfortable and well-built as the 3, with a right-slanted design that's made with rigid plastic, but it's still just as big and isn't any better suited for smaller hands.
If you want a more recent ergonomic office mouse with more convenient button placements, go with the 3. However, if you want something more affordable, go with the 2S.
The best ergonomic mouse with a vertical design that we've tested is the Logitech MX Vertical. This mouse has a unique design that sits upright in your palm, which allows you to rest your hand and wrist on your desk in a more neutral position. This should reduce strain in your wrist, though we don't test this. Because of its shape and the orientation of your hand, it's best suited for a palm or claw grip for most hand sizes.
It connects via Bluetooth or its proprietary receiver and can pair simultaneously with up to three different devices and quickly switch between them. Although you can't switch between custom profiles using the mouse buttons, you can use the Logitech Options software to assign different button configurations to different programs. You can also attach the charging cable to use it in wired mode, which reduces its latency significantly.
Unfortunately, it's bulky and doesn't have built-in storage for its wireless receiver, which might make it difficult to bring around. Also, the mouse wheel doesn't unlock for free scrolling, which might make office tasks more cumbersome. Due to its unique design, it might also take some time to get used to. Nonetheless, it's a great choice if you're looking for an exceptionally comfortable mouse with a vertical, ergonomic design.
If you want to try a vertical mouse but don't want to spend a lot on it, the Anker Wireless Vertical Mouse is a reasonable choice. While it doesn't support Bluetooth and it doesn't have customization software to remap buttons, it costs much less than the Logitech MX Vertical, which is great if you're not sure that you'll like the vertical shape. Also, it has storage space for its USB receiver, so you shouldn't need to worry about losing it when traveling. Despite its budget price, it feels well-built and has a smooth matte finish. Unfortunately, people with small hands might struggle to reach the scroll wheel and the first side button.
If you're looking for a vertical mouse with Bluetooth and customization software, get the Logitech. However, if you want a cheaper model just to test out the shape, go with the Anker.
The best ergonomic gaming mouse we've tested is the Razer Basilisk V2. This wired model has a slight slant and a thumb rest on its left side, which should make it comfortable for right hands. It's suitable for almost all hand sizes using a palm or claw grip, although people with small hands may struggle to reach the sniper button.
It feels very well-built, and its mouse feet glide very smoothly on mousepads and desks. The paracord-like cable is very lightweight and flexible, and it doesn't permanently kink. Performance-wise, it has a wide CPI range, with a CPI you can adjust precisely in increments of 50, a very low lift-off distance, and an amazingly low click latency. You can program all of its buttons except for the profile switching button, and you can also set a HyperShift button, which gives you a second layer of controls for as long as you hold it.
Unfortunately, it's quite heavy and bulky, which may be disappointing to fans of lighter mice. Overall, it's an excellent gaming mouse if you want a more ergonomic shape.
If you prefer ultra-light mice, check out the Cooler Master MM720. It doesn't have the right-slanting design and thumb rest of the Razer Basilisk V2, and its build quality doesn't feel quite as good, but it has a flatter, shorter shape with a ring finger rest and a honeycomb body that makes it exceptionally light. It also features an outstanding cable and feet that glide very smoothly across mousepads and tables, and it has a wide CPI range. However, you can only adjust the CPI by increments of 100, and the sensor tends to undershoot slightly when making quick mouse movements.
If you're looking for a well-rounded gaming mouse with excellent build quality and a right-slanted design that features a thumb rest, go with the Razer. If you're looking for a significantly lighter option that has a flatter, shorter shape with a ring finger rest and a honeycomb body, go with the Cooler Master.
The best ergonomic wireless mouse in the budget category that we've tested is the Logitech M720 Triathlon. It has an ergonomic, right-handed shape with a thumb rest on its left side that should feel comfortable to most people. You can pair it with up to three devices at once, via Bluetooth or its USB receiver.
There's a button below the scroll wheel to unlock free scrolling and a button on the thumb rest that enables gesture commands for as long as you hold it. Also, it has three side buttons, and the last one lets you easily switch between three paired devices. Some of its buttons are programmable through the Logitech Options app, including the two side buttons, the gesture button, the L/R wheel tilt buttons, and the scroll wheel click.
Unfortunately, its compact size makes it less suitable for people with larger hands using a palm or claw grip. Also, while its wireless capability makes it easier to travel with than a wired mouse, it's heavy and fairly bulky because of its high back, so it may not easily fit in all laptop cases. That said, this is an excellent office model if you want something wireless and ergonomic but are on a budget.
Sep 03, 2021: Replaced the XTRFY M42 with the XTRFY M4 RGB in the Notable Mentions because the M4's right-handed shape is more ergonomic than the M42's ambidextrous shape. Added the Glorious Model D to Notable Mentions.
Jul 06, 2021: Removed the Razer Basilisk Ultimate from Notable Mentions. Verified accuracy and availability of picks, and updated text for clarity.
May 07, 2021: Removed 'Vertical Alternative' from the budget category and moved the Anker Wireless Vertical Mouse to 'Cheaper Alternative' to the 'Best Vertical Mouse.' Added Razer Pro Click to Notable Mentions.
Mar 09, 2021: Replaced the Corsair Glaive Pro with the Razer Basilisk V2 for 'Best Ergonomic Gaming Mouse' as it has better performance, and added the Cooler Master MM720 as the 'Ultra-Light Alternative.' Replaced the Anker Wireless Vertical Mouse with the Logitech M720 Triathlon for the 'Best Budget Ergonomic Mouse' for its more conventional design and moved the Anker Wireless Vertical Mouse to be the 'Vertical Alternative.' Added the XTRFY M42 to Notable Mentions.
Jan 08, 2021: Minor text and structure changes, no change in recommendations.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.