If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long work day. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for the long-term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design and have easy-to-reach buttons.
We've tested over 75 mice, and below are our top picks for the best mouse for ergonomics. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best mouse for ergonomics that we've tested is the Logitech MX Master 3. It's the successor of the very popular Logitech MX Master 2S, with a similar ergonomic design that most people should find comfortable. It's designed for right-handed use and is better suited for medium to large hands due to its somewhat bulky size. Unfortunately, its bulky size also makes it less ideal for portable use, in addition to not having a compartment to store the wireless USB receiver.
Fortunately, if you don't want to use the wireless dongle, this mouse has Bluetooth support. It also has a multi-device pairing feature that allows you up to pair to three devices simultaneously, so you don't have to repeat the pairing process if you want to use the mouse with other devices. It has a total of eight buttons, six of which are programmable, and it has both a vertical and side scroll wheel. The vertical scroll wheel can be unlocked for infinite scrolling, which is great for scrolling through long documents quickly. There's even a button built into the thumb rest, which enables gesture control when held down.
There are many customization options that you can access through Logitech's Options software. You can remap buttons, change performance settings, and create custom profiles. There's no onboard memory, so software is required if you want to access your settings on a different computer. Also, its low polling rate can make cursor movements seem a bit jerky at times. Nonetheless, it's an outstanding and feature-packed mouse that should satisfy most people.
If you find the Logitech MX Master 3 too expensive, the Logitech MX Master 2s is still available and often at a reduced price. It shares many similarities with its successor, except that the side buttons are a bit harder to reach. Also, it has a slightly higher click latency, though it shouldn't be noticeable for most people. It has a higher polling rate to make cursor movements feel more fluid, and the feet provide a smoother glide. It has the same multi-device pairing feature, gesture control, and customization options.
Overall, the Logitech MX Master 3 is a more refined version of its predecessor and is a better choice for most people. However, if you're on a tight budget, the Logitech MX Master 2S is nearly identical, and you can often find it at a lower price.
The best vertical ergonomic mouse that we've tested is the Logitech MX Vertical. It's wireless and features a unique vertical design that allows for a more natural grip when compared to other mice. The plastic build feels quite sturdy, and the vertical design should feel comfortable for most people, although it may take some time to get used to it. It has a right-handed design and can be used most comfortably with a palm or claw grip.
It has an impressively wide CPI range, which can be adjusted in steps of 100, and the wireless click latency is decent enough that most people won't notice any lag. It's compatible with the Logitech Options companion software, where you can customize and save your settings to your account, which is handy as it's fully compatible with both Windows and macOS.
Unfortunately, due to the vertical design, a fingertip grip isn't possible. Also, its polling rate is pretty low, resulting in a choppy performance if used too quickly. The scroll wheel also can't be unlocked for infinite scrolling, and it feels much cheaper than the rest of the MX family. That said, this vertical mouse should encourage a more natural grip and is one of the best wireless mice we've tested.
The best mouse for ergonomics and gaming that we've tested is the Corsair GLAIVE PRO. It's worth noting that most gaming mice aren't necessarily designed with pure ergonomics in mind, but the slanted design and swappable grip options make this the best option if you want something comfortable for long gaming sessions. While it isn't the best gaming mouse that we've tested, this wired gaming mouse comes with three different side panels to help get you a comfortable fit, one with a thumb rest and two with different grip patterns.
The sensor performance is excellent, and it has a wide adjustable CPI range that can be set by increments of one, so you can fine-tune it to match your preferences. It has two additional side buttons, a CPI up and CPI down button on the top, and a scroll wheel click, all of which can be reprogrammed within Corsair's excellent iCUE software. The software is compatible with both Windows and macOS, which is fairly rare for a gaming mouse and allows you to customize every aspect.
Unfortunately, like many wired gaming mice, the cable is rather stiff and maintains a lot of kinks from its packaging. On the upside, it's suitable for a wide variety of hand sizes, and everyone should be able to easily reach every button with a claw grip, while only extra-large hands will likely have difficulties with a palm grip. Overall, if you're looking for a gaming mouse for extended gaming sessions, the slanted design and swappable grip panels make this the most comfortable option.
When it comes to the budget category, the best mouse for ergonomics that we've tested is the Anker Wireless Vertical Mouse. This wireless option has a fairly standard vertical design and feels surprisingly well-made for its low price point. It's very comfortable to use, and its vertical design puts your wrist in a more neutral position. It's designed to use with a palm grip, though its larger size means people with small hands may have difficulty reaching all the buttons comfortably.
While its click latency is quite high, it isn't designed for gaming, and it's unlikely that you'll notice any lag or delay in regular everyday use. Unfortunately, though its CPI is adjustable, even the lowest setting is high, which will result in cursor movement that may be too fast for most people, so you may need to change your cursor speed in your OS settings. Also, while it has two buttons that are well-placed by your thumb, there's no companion software, so you can't reprogram them without using third-party software.
Overall, this is a fairly decent ergonomic option that looks and feels more premium than its low price point may suggest. While we don't do any testing on the long-term effects of vertical mice, they're advertised as being more natural, and many people seem to find them more comfortable after using a computer all day at work. If you're curious about trying out a vertical mouse but don't want to spend a ton, this is a great choice.
10/08/2020: Minor text and structure changes, no change in recommendations.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.