If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for the long-term effects of ergonomic mice, the following mice all have a somewhat slanted and comfortable design and have easy-to-reach buttons.
We've tested over 90 mice, and below are our top picks for the best mouse for ergonomics. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best mouse for ergonomics that we've tested is the Logitech MX Master 3. It's the successor of the very popular Logitech MX Master 2S, with a similar ergonomic design that most people should find comfortable. It's designed for right-handed use and is better suited for medium to large hands due to its somewhat bulky size. There are many customization options that you can access through Logitech's Options software. You can remap buttons, change performance settings, and create custom profiles.
Fortunately, if you don't want to use the wireless dongle, this mouse has Bluetooth support. It also has a multi-device pairing feature that allows you to pair it with up to three devices simultaneously, so you don't have to repeat the pairing process if you want to use the mouse with other devices. It has a total of eight buttons, six of which are programmable, and it has a side scroll wheel. The vertical scroll wheel can be unlocked for infinite scrolling, which is great for going through long documents quickly. There's even a button built into the thumb rest, which enables gesture control when held down.
Unfortunately, its bulky size also makes it less ideal for portable use, in addition to not having a compartment to store the wireless USB receiver. There's no onboard memory, so software is required if you want to access your settings on a different computer. Also, its low polling rate can make cursor movements seem a bit jerky at times. Nonetheless, it's an outstanding, feature-packed mouse that should satisfy most people and, it's among the best mice we've tested.
If you’re looking for a cheaper ergonomic mouse that’s still remarkable for office use, check out the Logitech MX Master 2S. It’s the previous version of the Logitech MX Master 3, so it doesn’t have some of the newly added features such as a scroll wheel that automatically switches to infinite mode without the press of a button, or better-placed side buttons that are more easily accessible. That said, the Master 2S is less expensive and comes with better feet that glide more smoothly. It also feels extremely well-built and comfortable, thanks to the thumb rest and curved design that should match the shape of your hand. You can connect it with up to three devices simultaneously, either with Bluetooth or its USB receiver, and it has a decent amount of buttons to help you with your work. Unfortunately, it’s rather large and heavy, so it may not be suitable for people with smaller hands using any grip style.
If you want an ergonomic office mouse that's more recent and has upgraded features, get the Master 3, but if you’re looking for something more affordable, the Master 2S is an amazing choice.
The best vertical mouse that we’ve tested is the Logitech MX Vertical. This mouse’s design feels remarkably comfortable and aims for a more natural grip that should minimize wrist strain, though we don’t test for this. It also has excellent build quality, with no squeaking part or loose ends, and it’s suitable for most hand-sizes with a palm or claw grip.
It's great for office use, as it has good performance and amazing wireless connectivity options. You can pair it with up to three devices at the same time, either with Bluetooth or its receiver, and it’s rechargeable so you don’t have to worry about changing the batteries. It also has a reasonable amount of buttons to facilitate your work and a total of four programmable inputs to customize it to your liking.
Unfortunately, unlike the MX Master line, it doesn't have a horizontal scroll wheel, and it doesn't feel quite as well-built and premium. It’s also not very travel-friendly as it’s bulky and rather heavy, and it’s not suitable for a fingertip grip, no matter your hand size. On the plus side, the companion software is great and fully compatible with both Windows and macOS. All in all, this is a great option if you’re looking for a vertical mouse, and it’s also one of the best mice we’ve tested.
The best ergonomic mouse for gaming is the Corsair GLAIVE PRO. This wired-only mouse has a slight curve for right hands and textured grips on both sides that help make it feel very comfortable. This unique mouse includes three swappable side panels to help you find the best fit for your needs: one has a thumb rest, and the other two have different grip patterns.
It feels quite solidly built and exhibits very little flex, and even the removable side panel stays in place well. You can remap all of its buttons through the Corsair iCUE software, including the two side buttons, the scroll click, and the CPI up and down buttons below the scroll wheel. Also, it's fully compatible with both Windows and macOS, which is fairly rare for a gaming mouse. Its click latency is impressively low, and it has a very wide CPI range that can be precisely adjusted by increments of one, but sadly the sensor is a bit inconsistent.
Unfortunately, the braided cable is quite rigid and maintains kinks from its packaging. Since it's a wired-only mouse, it has no wireless options, so you can't connect it to multiple devices at once or use it without a cable. Nevertheless, if you're looking for a very good gaming mouse with ergonomic features, this is a great choice thanks to its swappable panels and slanted design.
When it comes to the budget category, the best mouse for ergonomics that we've tested is the Anker Wireless Vertical Mouse. While we don't do any testing on the long-term effects of vertical mice, they're advertised as being more natural, and many people seem to find them more comfortable after using a computer all day at work. This is a fairly decent ergonomic option that looks and feels more premium than its low price point may suggest.
This wireless option has a fairly standard vertical design and feels surprisingly well-made for its low price point. It's very comfortable to use, and its vertical design puts your wrist in a more neutral position. It's designed to use with a palm grip, though its larger size means people with small hands may have difficulty reaching all the buttons comfortably. While its click latency is quite high, it isn't designed for gaming, and it's unlikely that you'll notice any lag or delay in regular everyday use.
Unfortunately, though its CPI is adjustable, even the lowest setting is high, which results in cursor movement that may be too fast for most people, so you may need to change your cursor speed in your OS settings. Also, while it has two buttons that are well-placed by your thumb, there's no companion software, so you can't reprogram them without using third-party software. If you're curious about trying out a vertical mouse but don't want to spend a ton, this is a great choice.
01/08/2021: Minor text and structure changes, no change in recommendations.
11/10/2020: Replaced the Kensington Expert Mouse Wireless Trackball with the Logitech MX ERGO in the Notable Mentions.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.