If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for long term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design, and have easy-to-reach buttons.
We've reviewed over 50 mice, and below are our top picks for the best ergonomic mouse. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best ergonomic mouse for office use that we've reviewed so far is the Logitech MX Master 3. This very well-built and premium feeling wireless mouse is very comfortable thanks to its slanted design and thumb rest. It excels in office use, and has a second scroll wheel by your thumb to help you navigate both vertically and horizontally through large documents like Excel spreadsheets. It has two programmable side buttons, as well as customizable gesture controls that are activated by pressing a button on the thumb rest and moving the mouse in different directions.
The Logitech Options software can be installed on either Windows or macOS, meaning that you can fully use and customize this mouse for either OS. The main mouse wheel also automatically unlocks to activate infinite scroll when you need it, making it much easier to scroll through large documents or websites. While the latency and polling rate of this mouse aren't ideal for gamers, the mouse will still feel nice and responsive for regular office use.
Like most slanted mice, it's best used with either palm or claw grip, but due to its larger size, those with small hands will likely have a difficult time reaching all the buttons. Overall, this is a comfortable mouse with a nice big thumb rest and right-handed curve that should be comfortable enough for all-day use.
If you like the Logitech MX Master 3 but find its price tag a bit too high, check out the Logitech MX Master 2S. Its two side buttons are more awkwardly placed and difficult to press, but it performs very similarly and is available for much cheaper. Its shape is practically the same, and, like the other Logitech mouse, it can be used via Bluetooth or the included USB receiver. Unfortunately, it doesn't have the same great scroll wheel that automatically switches to infinite scrolling, and you'll have to switch manually by pressing a button. On the upside, the higher polling rate makes cursor movement slightly more fluid on your screen.
Overall, if you want the best ergonomic mouse for office use, get the MX Master 3; however, if you find it a bit too expensive and don't mind the button placement on the MX Master 2S, it's a great option that'll save you a fair amount of money.
The best vertical mouse that we've tested so far is the Logitech MX Vertical. Logitech claims that its vertical shape will help reduce muscle strain and wrist pressure, though it's worth noting that we don't test this and can't support these claims. That said, if you find the vertical shape comfortable, this is a great mouse for office and day-to-day use that should be comfortable enough to use all day.
Unfortunately, despite its name, it doesn't look or feel quite as premium as the rest of Logitech's MX line, like the Logitech MX Master 3. Like most vertical mice, it can't be used with a fingertip grip, but it should be comfortable enough to reach all the buttons with palm grip for everyone except those with extra-large hands, who will have to curl their fingers into a claw grip to prevent their fingers from going past the front of the mouse.
The mouse can be used wired, or wireless via Bluetooth or its USB receiver, which is great. While its click latency is fairly high when used wirelessly, it'll be fine for day-to-day use and most people won't notice any delay. Its performance is great, and it has four buttons which can be reprogrammed within its companion software. Overall, while it doesn't have the same premium feel and feature-set as other Logitech MX mice, this is a great mouse if you prefer its vertical design.
The best ergonomic mouse for gaming that we've tested is the Corsair GLAIVE PRO. It's worth noting that most gaming mice aren't necessarily designed with pure ergonomics in mind, but the slanted design and swappable grip options make this the best option if you want something comfortable for long gaming sessions. While it isn't the best gaming mouse we've tested so far, this wired gaming mouse comes with three different side panels to help get you a comfortable fit: one with a thumb rest, and two with different grip patterns.
The sensor performance is excellent, and it has a wide adjustable CPI range that can be set by increments of 1, so you can fine-tune it to match your preferences. It has two additional side buttons, a CPI up and CPI down button on the top, and a scroll wheel click, all of which can be reprogrammed within Corsair's excellent iCUE software. The software is compatible with both Windows and macOS, which is fairly rare for a gaming mouse and allows you to customize every aspect of the mouse.
Unfortunately, like many wired gaming mice, the cable is rather stiff and maintains a lot of kinks from its packaging. On the upside, the mouse is suitable for a wide variety of hand sizes, and everyone should be able to easily reach every button with a claw grip, while only extra-large hands will likely have difficulties with palm grip. Overall, if you're looking for a gaming mouse for extended gaming sessions, the slanted design and swappable grip panels make this the most comfortable option.
The best mouse for ergonomics in the budget category that we've tested so far is the Anker Wireless Vertical Mouse. This wireless mouse feels surprisingly well-built for its low price point, and its slim and tall vertical shape is very comfortable to hold. However, its rather large design will likely be too big for people with small hands to grip comfortably, but everyone else should have no problems. There are two side buttons that are well-placed by your thumb, but unfortunately, there's no companion software, so there's no way to reprogram them without using third-party software.
Unfortunately, its performance is only decent and the click latency is quite high, though this will likely be fine for regular day-to-day or office use. While the mouse's CPI can be adjusted via the CPI button on the top, it can only be set to 800, 1200, or 1600, all of which may be too high for most people and will result in a very quick-moving cursor. Luckily, you can change the sensitivity within the settings panel on Windows or macOS or use a third party piece of software; this won't change the actual CPI, but will make the cursor a more manageable speed.
Overall, while this mouse's performance isn't the best, it's a very comfortable and well-built vertical mouse that's available for considerably cheaper than the Logitech MX Vertical. If you use it in conjunction with a good third party piece of mouse customization software, it's a good option for fans of vertical mice.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our reviews of mice. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.