If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for long term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design, and have easy-to-reach buttons.
We've reviewed over 50 mice, and below are our top picks for the best ergonomic mouse. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The Logitech MX Master 3 is the best ergonomic mouse for office use that we've tested to date. This great wireless mouse has a slightly slanted shape, and a large thumb rest that makes it extremely comfortable to use, even for extended periods. It has a ton of connectivity options, and can be used with its included USB receiver (or piggyback off of any other Logitech Unifying receiver if you already use a Logitech keyboard that uses one), via Bluetooth, or wired while it's being charged via USB.
The mouse itself is rather large, so while anyone with medium or larger hands should find it comfortable, people with very small hands may have a difficult time reaching all the buttons. The performance of the mouse is great, and while it doesn't compete with gaming mice, it has a wide enough CPI range for regular use, and you can fine-tune and adjust it to match your own personal preferences. Its click latency is also low enough that most people shouldn't notice any lag or delay.
This mouse is compatible with Logitech's very good Options software, which lets you reprogram the buttons on the mouse. There's also a horizontal scroll wheel by your thumb, which is great for scrolling through large documents like Excel spreadsheets, and the regular mouse wheel automatically unlocks for infinite scrolling when triggered fast enough. Overall, this is an excellent mouse for office use and is among the best mice we've tested so far.
If you're shopping on a tight budget, take a look at the Logitech MX Master 2S. Its design and features are very similar to the Logitech MX Master 3, but it's slightly heavier and its side buttons are a bit harder to press due to their placement. There are five programmable buttons and it has a slightly higher polling rate, which makes mouse movements feel a bit smoother. You still get great customization options through its companion software as well as excellent compatibility with Windows and macOS, and it can be paired to 3 devices at the same time to make multitasking a breeze.
Overall, the Logitech MX Master 3 is slightly better if you can afford it, but the MX Master 2S can perform almost as well and is significantly cheaper.
The best vertical mouse that we've tested so far is the Logitech MX Vertical. It's a mouse that's designed to limit pronation of the forearm, which can help reduce pressure on the inner wrists, though this is not something that we specifically test for. It's made for right-handed use, and due to its size and button placement, it's not suitable for those with a fingertip grip. It has a unifying USB receiver and Bluetooth capabilities, allowing it to be paired to three devices at the same time, so you can switch between them for better multitasking.
When used wirelessly, its click latency is decent and doesn't change whether you're using it with the dongle or through Bluetooth. It has a wide CPI range, but unfortunately, its polling rate is quite low, making fast mouse movements feel less fluid. There are seven buttons in total, four of which are programmable through Logitech's Options software. The latter is fully compatible with Windows and macOS, and it can also store profiles, though it can only save one profile per program. This mouse doesn't have onboard memory, which means that if you want to export your settings, you 'll need to create an account with Logitech and install the customization software on the new computer.
On the whole, this is a great mouse with a design that may take some time to get used to, but one that most people should be satisfied with.
The best ergonomic mouse for gaming that we've tested is the Corsair GLAIVE PRO. It's worth noting that most gaming mice aren't necessarily designed with pure ergonomics in mind, but the slanted design and swappable grip options make this the best option if you want something comfortable for long gaming sessions. While it isn't the best gaming mouse we've tested so far, this wired gaming mouse comes with three different side panels to help get you a comfortable fit: one with a thumb rest, and two with different grip patterns.
The sensor performance is excellent, and it has a wide adjustable CPI range that can be set by increments of 1, so you can fine-tune it to match your preferences. It has two additional side buttons, a CPI up and CPI down button on the top, and a scroll wheel click, all of which can be reprogrammed within Corsair's excellent iCUE software. The software is compatible with both Windows and macOS, which is fairly rare for a gaming mouse and allows you to customize every aspect of the mouse.
Unfortunately, like many wired gaming mice, the cable is rather stiff and maintains a lot of kinks from its packaging. On the upside, the mouse is suitable for a wide variety of hand sizes, and everyone should be able to easily reach every button with a claw grip, while only extra-large hands will likely have difficulties with palm grip. Overall, if you're looking for a gaming mouse for extended gaming sessions, the slanted design and swappable grip panels make this the most comfortable option.
The best ergonomic mouse in the budget category that we've tested to date is the Anker Wireless Vertical Mouse. This wireless mouse has a fairly standard vertical design and feels surprisingly well-made for its low price point. It's very comfortable to use and its vertical design puts your wrist in a more neutral position. It's designed to use with a palm grip, though its larger size means people with small hands may have difficulty reaching all the buttons comfortably.
While its click latency is quite high, this mouse isn't designed for gaming and it's unlikely that you'll notice any lag or delay in regular everyday use. Unfortunately, though its CPI is adjustable, even the lowest setting is high, which will result in cursor movement that may be too fast for most people, so you may need to change your cursor speed in your OS settings. Also, while the mouse has two buttons that are well-placed by your thumb, there's no companion software, so you can't reprogram them without using third-party software.
Overall, this is a fairly decent ergonomic mouse that looks and feels more premium than its low price point may suggest. While we don't do any testing on the long-term effects of vertical mice, they're advertised as being more natural and many people seem to find them more comfortable after using a computer all day at work. If you're curious about trying out a vertical mouse but don't want to spend a ton, this is a great choice.
03/23/2020: Minor text and structure changes, no change in recommendations.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our reviews of mice. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.