If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long workday. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for the long-term effects of ergonomic mice, the following mice all have a somewhat slanted and comfortable design and have easy-to-reach buttons.
We've tested over 100 mice, and below are our top picks for the best mouse for ergonomics. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best mouse for ergonomics that we've tested is the Logitech MX Master 3. It's the successor of the very popular Logitech MX Master 2S, with a similar ergonomic design that most people should find comfortable. It's designed for right-handed use and is better suited for medium to large hands due to its somewhat bulky size. There are many customization options that you can access through Logitech's Options software. You can remap buttons, change performance settings, and create custom profiles.
Fortunately, if you don't want to use the wireless dongle, it has Bluetooth support. It also has a multi-device pairing feature that allows you to pair it with up to three devices simultaneously, so you don't have to repeat the pairing process if you want to use the mouse with other devices. It has a total of eight buttons, six of which are programmable, and it has a side scroll wheel. The vertical scroll wheel can be unlocked for infinite scrolling, which is great for going through long documents quickly. There's even a button built into the thumb rest, which enables gesture control when held down.
Unfortunately, its bulky size also makes it less ideal for portable use, in addition to not having a compartment to store the wireless USB receiver. There's no onboard memory, so software is required if you want to access your settings on a different computer. Also, its low polling rate can make cursor movements seem a bit jerky at times. Nonetheless, it's an outstanding, feature-packed mouse that should satisfy most people and, it's among the best mice we've tested.
If you’re looking for a cheaper ergonomic mouse that’s still remarkable for office use, check out the Logitech MX Master 2S. It’s the previous version of the Logitech MX Master 3, so it doesn’t have some of the newly added features, like a scroll wheel that automatically switches to infinite mode without the press of a button or better-placed side buttons that are more easily accessible. That said, the Master 2S is less expensive and comes with better feet that glide more smoothly. It also feels extremely well-built and comfortable, thanks to the thumb rest and curved design that should match the shape of your hand. You can connect it with up to three devices simultaneously, either with Bluetooth or its USB receiver, and it has a decent amount of buttons to help you with your work. Unfortunately, it’s rather large and heavy, so it may not be suitable for people with smaller hands using any grip style.
If you want an ergonomic office mouse that's more recent and has upgraded features, get the Master 3, but if you’re looking for something more affordable, the Master 2S is an amazing choice.
The best vertical mouse that we’ve tested is the Logitech MX Vertical. Its design feels remarkably comfortable and aims for a more natural grip that should minimize wrist strain, though we don’t test for this. It also has excellent build quality, with no squeaking part or loose ends, and it’s suitable for most hand-sizes with a palm or claw grip.
It's great for office use, as it has good performance and amazing wireless connectivity options. You can pair it with up to three devices at the same time, either with Bluetooth or its receiver, and it’s rechargeable so you don’t have to worry about changing the batteries. It also has a reasonable amount of buttons to facilitate your work and a total of four programmable inputs to customize it to your liking.
Unfortunately, unlike the MX Master line, it doesn't have a horizontal scroll wheel, and it doesn't feel quite as well-built and premium. It’s also not very travel-friendly as it’s bulky and rather heavy, and it’s not suitable for a fingertip grip, no matter your hand size. On the plus side, the companion software is great and fully compatible with both Windows and macOS. All in all, this is a great option if you’re looking for a vertical mouse, and it’s also one of the best mice we’ve tested.
The best ergonomic mouse for gaming that we've tested is the Razer Basilisk V2. It has a right-sloping design that features a thumb rest, and it's very comfortable to use, even during long gaming sessions. It has an excellent build quality, three side buttons, and you can set a HyperShift command to enable a secondary layer of controls.
It has a very low click latency, a high maximum CPI, a low CPI variation, and a low minimum lift-off distance, as well as excellent companion software that allows you to make sensor adjustments, program buttons, and customize RGB lighting. The Razer also features custom profile storage onboard the mouse, a scroll wheel with L/R inputs that also unlock for free scrolling, and a very lightweight and flexible cable.
Unfortunately, it's a little heavy and bulky, so it may not be the best to take around with you on-the-go. It also may be a bit too large if you have small hands, and you might not be able to reach all buttons using a claw or fingertip grip. Nonetheless, it's an outstanding, versatile gaming mouse that should please gamers who prefer an ergonomic design.
If you prefer ultra-light mice, check out the Cooler Master MM720. It doesn't have the right-slanting design and thumb rest of the Razer Basilisk V2, and its build quality doesn't feel quite as good, but it has a flatter, shorter shape with a ring finger rest and a honeycomb body that makes it exceptionally light. It also features an outstanding cable and feet that glide very smoothly across mousepads and tables, and it has a wide CPI range. However, you can only adjust the CPI by increments of 100, and the sensor tends to undershoot slightly when making quick mouse movements.
If you're looking for a well-rounded gaming mouse with excellent build quality and a right-slanted design that features a thumb rest, go with the Razer. If you're looking for a significantly lighter option that has a flatter, shorter shape with a ring finger rest and a honeycomb body, go with the Cooler Master.
The Logitech M720 Triathlon is the best budget ergonomic office mouse we've tested. It has a right-handed ergonomic shape with a high back, rubberized side, a thumb rest, and a professional style very similar to the Logitech MX Master 2S and Logitech MX Master 3.
It connects wirelessly, either with a USB receiver or via Bluetooth. You can also pair it wirelessly with up to three devices, and you can switch between them using the third side button. It also features easy-to-use companion software that is fully compatible with Windows and macOS. The software allows you to reprogram most of the buttons, and while you can't change the default CPI, there is a cursor speed option. The mouse has 10 programmable buttons, including four side buttons and L/R mouse wheel inputs. It also has a button below the wheel that unlocks it for infinite scrolling.
Unfortunately, if you have large or extra-large hands, you may find it too small to use anything other than a fingertip grip, and its click latency is very low, although most people likely won't notice any delays while performing regular office tasks. Overall, the Logitech is a very comfortable and professional-looking office mouse that performs amazingly well considering its budget price point.
If you'd prefer a vertical option, check out the Anker Wireless Vertical Mouse. It doesn't have user-friendly companion software or the more conventional, professional style of the Logitech M720 Triathlon, but its design keeps your wrist in a comfortable, neutral position, and it's surprisingly well-built and durable-feeling for its price. It connects wirelessly with an included USB receiver, but it doesn't work with Bluetooth. It has two well-placed side buttons and a large button for changing the CPI directly on the mouse, but since there's no companion software, none of the buttons are programmable. The CPI is adjustable, but even the minimum setting may seem slightly fast for some people. Lastly, as a vertical mouse, it isn't suitable for fingertip grip, and if you have small hands, you may have trouble reaching all of the buttons using any grip type.
If you're looking for an office mouse with user-friendly companion software and a more traditional shape and design, go with the Logitech. If you'd prefer something that keeps your wrist in a more neutral position and has an impressive build quality, especially given its price point, go with the Anker.
Mar 09, 2021: Replaced the Corsair Glaive Pro with the Razer Basilisk V2 for 'Best Ergonomic Gaming Mouse' as it has better performance, and added the Cooler Master MM720 as the 'Ultra-Light Alternative.' Replaced the Anker Wireless Vertical Mouse with the Logitech M720 Triathlon for the 'Best Budget Ergonomic Mouse' for its more conventional design and moved the Anker Wireless Vertical Mouse to be the 'Vertical Alternative.' Added the XTRFY M42 to Notable Mentions.
Jan 08, 2021: Minor text and structure changes, no change in recommendations.
Nov 10, 2020: Replaced the Kensington Expert Mouse Wireless Trackball with the Logitech MX ERGO in the Notable Mentions.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.