If you use your mouse all day for work, you may find the straight, ambidextrous design of most mice uncomfortable by the end of a long work day. There are many mice these days that are designed with a slanted shape or a thumb rest to help with ergonomics and create a more comfortable user experience. While we don't test for long term effects of ergonomic mice, the following mice all have an at least somewhat slanted and comfortable design and have easy-to-reach buttons.
We've reviewed over 65 mice, and below are our top picks for the best ergonomic mouse. If you don't mind something with a less ergonomic shape, check out our recommendations for the best wireless mice, the best mice, and the best wired mice.
The best ergonomic mouse we've tested so far is the Logitech MX Master 3. It's an incredibly well-built and comfortable mouse that comes with tons of features to help you get work done. The mouse is only available for right-handers and its bulky size makes it more ideal for medium to large hands. It works well with palm and claw grips, but unless you have very large hands, it can be difficult to reach all the buttons with a fingertip grip. It has a soft latex finish that provides a good grip, giving you greater control of the mouse. There are two scroll wheels for vertical and horizontal scrolling, and the vertical scroll wheel can be unlocked to allow for infinite scrolling.
This mouse uses a laser sensor with a wide CPI range; however, it has a low 90Hz polling rate, which can sometimes result in jerky cursor movements. You can switch between different CPI settings directly on the mouse or through Logitech's Options software. The latter also allows you to reprogram buttons and save profiles, which are saved per application. It has decent wireless latency through Bluetooth, and it's slightly lower if you use the unifying USB receiver. Unfortunately, the provided USB-C cable is only for charging, so you can't use it wired.
There's a multi-device pairing feature that allows you to pair up to three devices simultaneously and you can switch between the paired devices with just a press of a button. There's a total of eight buttons, six of which are programmable, and there's a button on the thumb rest that enables gesture commands for as long as you hold the button down. It's fully compatible with Windows and macOS, although some programmable functions are OS-specific. Overall, this is a feature-rich mouse that's comfortable to use all day long.
If you're shopping on a tighter budget, then check out the Logitech MX Master 2S. It's the predecessor of the Logitech MX Master 3, and since it's an older model, you can often find it at a reduced price. They're very similar in design, but there are some small differences in button placement on the thumb side, as some of those buttons aren't as easy to reach on this model. Other than that, it has mostly the same features as its successor. It also supports gesture control and its multi-device pairing feature allows you to pair up to three devices at the same time. Its wireless latency is good enough for most productivity tasks but may be too high for fast-paced gaming.
Overall, the MX Master 3 is a better choice for most people, as the thumb buttons are much easier to use; however, if you're on a small budget and you don't mind compromising a bit, the MX Master 2S is an excellent alternative.
The best vertical mouse that we've tested so far is the Logitech MX Vertical. Vertical mice aim to reduce the pronation of the forearm and put your arm in a more natural position. This should help people that feel a lot of tension in their wrist or forearm after a long work day. This mouse is from the professional MX lineup, just like the Logitech MX Master 3 and the Logitech MX Master 2. It's very well-built and its design is better suited for a palm grip.
Its overall wireless performance is good enough for the office, but won't be on-par with gaming mice, which is to be expected. You can use this mouse via Bluetooth, with its USB receiver, or even when charging with a cable, making it quite versatile. It's easy to use, although some people might require a bit of time to get used to its vertical design.
Its very large body won't be great for people with small hands as they might have trouble reaching the scroll wheel. Also, even if it's Bluetooth-enabled, bringing it around is a bit difficult, so it's best to stay at your work desk. On the upside, just like most Logitech mice, it's fully compatible and customizable on macOS and Windows.
The best ergonomic mouse for gaming that we've tested is the Corsair GLAIVE PRO. It's worth noting that most gaming mice aren't necessarily designed with pure ergonomics in mind, but the slanted design and swappable grip options make this the best option if you want something comfortable for long gaming sessions. While it isn't the best gaming mouse we've tested so far, this wired gaming mouse comes with three different side panels to help get you a comfortable fit: one with a thumb rest, and two with different grip patterns.
The sensor performance is excellent, and it has a wide adjustable CPI range that can be set by increments of 1, so you can fine-tune it to match your preferences. It has two additional side buttons, a CPI up and CPI down button on the top, and a scroll wheel click, all of which can be reprogrammed within Corsair's excellent iCUE software. The software is compatible with both Windows and macOS, which is fairly rare for a gaming mouse and allows you to customize every aspect of the mouse.
Unfortunately, like many wired gaming mice, the cable is rather stiff and maintains a lot of kinks from its packaging. On the upside, the mouse is suitable for a wide variety of hand sizes, and everyone should be able to easily reach every button with a claw grip, while only extra-large hands will likely have difficulties with palm grip. Overall, if you're looking for a gaming mouse for extended gaming sessions, the slanted design and swappable grip panels make this the most comfortable option.
The best ergonomic mouse in the budget category that we've tested to date is the Anker Wireless Vertical Mouse. This wireless mouse has a fairly standard vertical design and feels surprisingly well-made for its low price point. It's very comfortable to use and its vertical design puts your wrist in a more neutral position. It's designed to use with a palm grip, though its larger size means people with small hands may have difficulty reaching all the buttons comfortably.
While its click latency is quite high, this mouse isn't designed for gaming and it's unlikely that you'll notice any lag or delay in regular everyday use. Unfortunately, though its CPI is adjustable, even the lowest setting is high, which will result in cursor movement that may be too fast for most people, so you may need to change your cursor speed in your OS settings. Also, while the mouse has two buttons that are well-placed by your thumb, there's no companion software, so you can't reprogram them without using third-party software.
Overall, this is a fairly decent ergonomic mouse that looks and feels more premium than its low price point may suggest. While we don't do any testing on the long-term effects of vertical mice, they're advertised as being more natural and many people seem to find them more comfortable after using a computer all day at work. If you're curious about trying out a vertical mouse but don't want to spend a ton, this is a great choice.
07/31/2020: Minor text and structure changes, no change in recommendations.
Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).
If you would like to do the work of choosing yourself, here is the list of all our reviews of mice. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.