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The Best Ergonomic Mouse - Summer 2022 Mice Reviews

Best Ergonomic Mouse

As many of us are spending more time with our computers, you may find the straight, ambidextrous designs of most mice uncomfortable at the end of long workdays or gaming sessions. Thankfully, there are an increasing number of mouse designs with sculpted shapes, thumb rests, and other ergonomic elements. These elements can help contribute to a more comfortable experience. The following mice are a selection of the best of these designs focusing on ergonomic compatibility, button reachability, and comfort.

We've tested over 260 mice, and below are our top picks for the best ergonomic options. For other recommendations, be sure to check out our picks for the best wireless mice, the best mice, and the best wired mice.

  1. Best Ergonomic Mouse

    The best ergonomic mouse we've tested is the Logitech MX Master 3S. It's the latest entry in Logitech's MX Master series of mice, and it shares the same right-handed, ergonomic shape as other entries in the series. Its body is made of solid plastic with a soft-touch texture, and it's incredibly well-built. However, it's on the larger side and is most comfortable for medium-sized or larger hands. You can press its large thumb rest section to enable gesture controls, and its primary scroll wheel unlocks automatically for faster free-scrolling whenever you're scrolling quickly through a long document or website. There's also a side-mounted scroll wheel within reach of your thumb that you can use to scroll horizontally, which is helpful if you deal with spreadsheets or timelines. You can connect wirelessly with its USB receiver or via Bluetooth and pair it with up to three devices simultaneously.

    This version features quieter click buttons and an improved sensor with a wider CPI range, which is especially useful if you use a 4k display. If these features don't interest you, we recommend checking out the older Logitech MX Master 2S. Its side buttons aren't as ergonomically placed, and it uses an older micro-USB charging cable as opposed to USB-C, but it's less expensive than newer models in the lineup. However, it's starting to get harder to find in stock from some retailers.

    See our review

  2. Best Mid-Range Ergonomic Mouse

    At a mid-range price point, we recommend the Logitech Lift. This mouse has a vertical design, which means you hold it in a 'handshake position' This design is intended to reduce wrist strain by allowing you to rest your hand and wrist on your desk, avoiding pronation that can compress nerves in your forearm and wrist. This pick is a bit smaller than many of the options on this list, making it a great choice if you have small or medium-sized hands. Also, there's a left-handed version of this mouse available. Overall, this mouse feels very well-built and has a textured rubberized surface that provides additional grip. It has very quiet clicks and a scroll wheel that automatically switches between a notched scrolling mode and a much quicker free-scrolling mode.

    This mouse is available in three colors that blend well into both office and home setups. You can connect it wirelessly via Bluetooth or its USB receiver, it has an advertised battery life of up to 24 months, and you can pair it with up to three devices simultaneously. If you're interested in a cheaper option, consider the Anker Wireless Vertical Mouse. Its size makes it a better fit for larger hands. However, it doesn't perform as well and lacks both Bluetooth support and multi-device pairing.

    See our review

  3. Best Budget Ergonomic Mouse

    In the budget category, we recommend the Logitech M720 Triathlon. It shares many of the same work-oriented features as Logitech's more premium MX Master series mice, but it's significantly less expensive. It has a right-handed, ergonomic shape with a small thumb rest and three buttons on the left. It also has a rubberized coating for added grip. It connects wirelessly with its USB receiver or via Bluetooth, and you can pair it with up to three devices at once. It uses a single AA battery for power and has an impressive advertised battery life of up to 24 months. The scroll wheel also unlocks for free-scrolling and has left and right tilt buttons for horizontal scrolling. There's also a hidden button in the thumb rest that enables gesture commands.

    Unfortunately, its shape and high palm rest make this mouse pretty bulky, so it isn't the most portable option. Also, its mouse feet are on the thinner side and have sharp edges that can dig into softer mousepads a bit. That said, it's a versatile option that combines many helpful productivity features into an affordable package that's very comfortable for just about all hand sizes.

    See our review

  4. Best Ergonomic Mouse For Gaming

    The best ergonomic gaming mouse we've tested is the Razer Basilisk V3. It has a right-handed shape with a thumb rest that provides more ergonomic support than typical gaming mice. Also, while many gaming mice have only two side buttons, this one has three. As an added feature, its wheel has L/R tilt inputs and a free-scrolling mode that you can toggle to automatically enable when you scroll to a certain speed, like some of the more work-oriented picks on this list. Using the companion software, you can reprogram any of the buttons, make sensor adjustments, and customize the RGB lighting.

    Unfortunately, this mouse is on the heavier side, so it might not be ideal if you only play fast-paced, reaction-based games. If you're interested in a much lighter and less expensive alternative, check the Cooler Master MM720. Unlike the Razer mouse, which has a thumb rest on the left, this mouse has added ergonomic support on the right side and features a rest for your ring finger. It doesn't have as many buttons and lacks extra features like a scroll wheel with free-scrolling mode. It also has honeycomb cutouts in its body, and while these contribute to making it extremely lightweight, they change the look and feel of the mouse.

    See our review

  5. Best Trackball Ergonomic Mouse

    If you're interested in a trackball design, we recommend the Logitech MX ERGO. It has a comfortable right-handed shape and a thumb trackball design suitable for all hand sizes. It also includes a metal plate that lets you adjust between a zero or 20-degree tilt position, and there's a pinky rest area, so none of your fingers hang awkward off the side. Overall, this mouse is very well-built, and the materials are high quality. However, it doesn't feel as premium as the Logitech MX Master 3S. Some users also report the rubber coating can be prone to wearing out from heavy use.

    This mouse connects wirelessly using its USB receiver or via Bluetooth. It has an advertised battery life of up to four months, and you can pair up to two devices simultaneously. The scroll wheel has tilt buttons for horizontal scrolling but doesn't unlock for a quicker free-scrolling mode like some productivity mice. Using the customization software, you can also reprogram buttons to best suit your needs. If you're interested in a cheaper alternative, consider the Logitech ERGO M575. It has the same ergonomic shape; however, it doesn't include a tilt base, doesn't support multi-device connectivity, and feels cheaper overall.

    See our review

Notable Mentions

  • Microsoft Sculpt Ergonomic Mouse: The Microsoft Sculpt Ergonomic Mouse is designed for office use and general productivity tasks. It features a bulbous, right-handed shape with a scoop-shaped thumb rest area. It also has a tilted orientation, a bit like a vertical mouse, to promote a more natural wrist posture. Unfortunately, it lacks both Bluetooth connectivity and extra features like gesture support and a scroll wheel with a free-scrolling mode. See our review
  • Logitech G604 LIGHTSPEED: The Logitech G604 LIGHTSPEED is a wireless gaming mouse that's also a viable work option. It has a similar ergonomic shape and features as the Razer Basilisk V3. It also has Bluetooth support. However, it's quite a bit heavier, uses disposable AA batteries for power, and doesn't support gesture controls or have a second scroll wheel like mice in Logitech's MX Master series. See our review
  • Mad Catz R.A.T. DWS: The Mad Catz R.A.T. DWS is a decent wireless gaming option with a design that allows you to customize the length of the mouse and swap out differently shaped side panels. However, it's heavier and doesn't perform as well as the Razer Basilisk V3. See our review

Recent Updates

  1. Sep 01, 2022: We've revamped the category names and our picks for this article to better represent the current market and to provide more insight for readers. We've also overhauled our Notable Mentions section to include fewer, more relevant recommendations.

  2. Apr 22, 2022: We've transformed the 'Cheaper Alternative' category into a new 'Best Budget Vertical Mouse' category, keeping the Anker Wireless Vertical Mouse as our pick. We've also confirmed all other choices for relevance and continued availability, and we made minor adjustments to the text for clarity.

  3. Feb 22, 2022: Made several minor changes to the text for clarity and confirmed all recommendations remain the best choices currently available for their respective categories.

  4. Dec 24, 2021: Moved the Cooler Master MM720 to 'Best Ultra-Light Ergonomic Mouse For Gaming'. Replaced the Razer Basilisk V2 with the Razer Basilisk V3 as 'Best Ergonomic Mouse For Gaming' for consistency across articles. Added the Logitech MX ERGO as 'Best Ergonomic Trackball Mouse'.

  5. Nov 02, 2021: Verified picks for accuracy and availability; no changes to picks.

All Reviews

Our recommendations above are what we think are currently the best ergonomic mice for most people. We factor in the price (a cheaper mouse wins over a pricier one if the difference isn't worth it), feedback from our visitors, and availability (no mice that are difficult to find or almost out of stock everywhere).

If you would like to do the work of choosing yourself, here is the list of all our mice reviews. Be careful not to get too caught up in the details. While no mouse is perfect for every use, most mice are great enough to please almost everyone, and the differences are often not noticeable unless you really look for them.